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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Clin Ther. 2019 Apr 28;41(5):848–863. doi: 10.1016/j.clinthera.2019.04.009

Table 3.

Major pathways/genes modulated by EBV-dUTPase protein in female C57Bl/6 mouse brain.

Gene Symbol Gene Name Fold-Regulation* P Function
Alox12 Arachidonate 12-lipoxygenase −1.91324 0.030 Signal transduction phospholipase A2 pathway
Arrb1 Beta-ARRESTIN 1/negative regulators of GPCR −1.60338 0.012 Signal transduction G-protein coupled receptor regulation
Cgn cingulin −1.62 0.049 Blood—brain barrier
Dbh dopamine β-hydroxylase (DβH) enzyme −1.7011 0.030 Dopamine metabolism
Drd1 Dopamine receptor D1 −1.75465 0.025 Dopamine receptor
Drd5 Dopamine receptor D5 −1.70713 0.032 Dopamine receptor
Egr1 Early growth response 1  1.74 0.046 Synaptic plasticity; pain
Fos Transcription factor/essential role in stress resilience −1.61098 0.033 Signal transduction; cAMP & protein kinase A signaling
Gabrd GABAA receptor subunit δ  1.58754 0.017 Neurotransmitter receptor: GABAergic synapse
Gch1 GTP cyclohydrolase  2.94 0.016 Pain; dopamine biosynthesis
Grik4 Glutamate receptor, ionotropic, kainite subunit KA1  2.91804 0.016 Neurotransmitter receptor glutamatergic synapse
Grik5 Glutamate receptor, ionotropic, kainite subunit KA2  1.74256 0.024 Neurotransmitter receptor glutamatergic synapse
Grk6 G protein-coupled receptor kinase 6 −1.5332 0.033 Regulation of dopamine receptors
Gpr84 G protein-coupled receptor 84 −3.00 0.015 Pain
Gpr171 G protein-coupled receptor 171 −1.73 0.022 Energy/metabolism
Il1b Interleukin-1β  2.0868 0.016 Immune
Kmo Kynurenine-3-monooxygenase −2.18 0.050 Tryptophan metabolism
Lin 7B Lin 7 homolog B −3.55 0.045 Synaptic plasticity
Mmp15 Metalloprotease 15 −1.83 0.049 Blood—brain barrier
Nr4a1 Nuclear receptor Nur77 −1.58885 0.023 Dopamine & serotonin target
Pde10a Phosphodiesterase 10A −1.51367 0.024 Signal transduction Phospholipase A2 pathway
Pik3cg Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma −1.52318 0.031 Signal transduction AKT andPI3 kinase signaling
Plcb1 Phospholipase C β1 −1.52803 0.031 Signal transduction phospholipase C signaling
Rab33a RAB33A member of Ras oncogene family −3.67 0.018 Synaptic plasticity
Rapgef6 Rap guanine nucleotide exchange factor 6 −1.61 0.019 Blood—brain barrier
Rgs20 Regulator of G protein signaling −1.65 0.029 Synaptic plasticity
Slc6a3 Dopamine transporter (DAT1) −1.5978 0.042 Dopamine transporter
Slc6a4 Solute carrier family 6α member 4/serotonin transporter −5.76338 0.033 Serotonin transporter
Synpo Synptopodin −2.25 0.036 Synaptic plasticity
Tbc1d1 TBC1 family domain member 1 −1.55 0.042 Energy/metabolism
Th Tyrosine hydroxylase/involved in dopamine synthesis −2.23353 0.013 Dopamine metabolism
Tjp2 Tight junction protein 2 −2.68 0.023 Blood—brain barrier
Tph2 tryptophan hydroxylase 2 −3.77918 0.010 Serotonin metabolism

Data represent mRNA expression levels relative to the control and expressed as fold-regulation.

AKT = protein kinase B; cAMP = cyclic adenosine monophosphate; dUTPase = deoxyuridine triphosphate nucleotidohydrolase; EBV = Epstein-Barr virus; GABA = γ-aminobutyric acid; GPCR = G protein-coupled receptor; IL = interleukin; PI3 = phosphoinositide 3; TBC1 = TBC1 family domain member 1.

*

Mean fold-change in expression significantly different from control by ≥ 1.5, n = 3.