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Glutamine synthetase activity is diminished in Huntington’s disease (HD). Glutamine synthetase is an Mn-dependent enzyme. Efficient glutamate uptake by astrocytes relies on glutamine synthetase. In HD, where cellular Mn is reduced, impaired glutamine synthetase activity inhibits glutamate uptake. Abbreviations: Gln, glutamine; Glu, glutamate; GS, glutamine synthetase; Mn, manganese.
