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. Author manuscript; available in PMC: 2019 May 19.
Published in final edited form as: Annu Rev Nutr. 2015 May 13;35:71–108. doi: 10.1146/annurev-nutr-071714-034419

Table 1.

Known manganese (Mn) transporters

Type of Mn transporter Name Localization Function Primary metal of transport
Uptake DMT1 Plasma membrane Transports divalent metal cations (Co2+, Fe2+, Mn2+, Ni2+, Pb2+, and Zn2+) across cell membrane using proton gradient Fe
Uptake Transferrin Plasma membrane Transports Fe and Mn across plasma membrane by endocytosis via transferrin receptor Fe
Uptake Ceruloplasmin Plasma membrane Oxidizes and mobilizes Fe Fe
Uptake ZIP8/ZIP14 Plasma membrane Divalent ion/HCO3− symporters; transport metals across HCO3− gradient Zn
Uptake Citrate transporter Plasma membrane Chelates metals, including Mn
Uptake Choline transporter Plasma membrane Transports choline into neurons
Uptake Dopamine transporter Plasma membrane Releases dopamine
Uptake Calcium channels Plasma membrane Voltage-gated, receptor, and store-operated ion channels Ca
Efflux Ferroportin Plasma membrane Removes Fe and Mn from cells Fe
Efflux NCX Plasma membrane Removes Ca from cells via influx of Na ions Ca/Na
Efflux, subcellular SLC30A10 Plasma membrane, Golgi, endosome Cell-surface Mn export Mn
Subcellular Park9/ATP13A2 Lysosome P-type ATPase; shuttles cations across lysosomal membrane Mn
Subcellular SPCA1 Golgi membrane Ca2+/Mn2+ ATPase; transports cytosolic Ca2+ and Mn2+ into Golgi lumen Mn/Ca
Subcellular HIP14/HIP14L Golgi membrane Transports divalent metals; palmitoylates Htt and synaptic proteins Mg
Subcellular Calcium channels Golgi membrane Voltage-gated, receptor, and store-operated ion channels Ca

Abbreviations: AtP13A2, ATPase type 13A2; DMT1, divalent metal transporter 1; HCO3, bicarbonate; HIP14/HIP14L, huntingtin-interacting protein 14/14-like; NCX, sodium-calcium exchanger; SLC, solute carrier; SPCA1, secretory pathway Ca2+-ATPase isoform 1.