Table 4.
Genotype association analysis with these SNPs.
| Gene/SNP | XFS/XFG | Control | p | OR (95% CI) | Adjusted-P | Adjusted-OR (95% CI) |
|---|---|---|---|---|---|---|
| TBC1D21 | ||||||
| rs16958445 | ||||||
| Genotype | ||||||
| GG | 189 | 259 | 0.532 | 1.138 (0.758–1.71) | 0.114 | 1.465 (0.913–2.351) |
| GA | 54 | 65 | 0.033 | 5.481 (1.151–26.110) | 0.043 | 5.439 (1.053–28.090) |
| AA | 8 | 2 | ||||
|
| ||||||
| ATXN2 | ||||||
| rs7137828 | ||||||
| Genotype | ||||||
| TT | 183 | 224 | 0.705 | 0.929 (0.635–1.360) | 0.955 | 1.013 (0.654–1.569) |
| TC | 63 | 83 | 0.027 | 0.322 (0.118–0.879) | 0.030 | 0.299 (0.100–0.891) |
| CC | 5 | 19 | ||||
|
| ||||||
| APOE | ||||||
| rs429358 | ||||||
| Genotype | ||||||
| TT | 202 | 263 | 0.910 | 1.025 (0.673–1.560) | 0.532 | 1.171 (0.714–1.920) |
| TC | 48 | 61 | 0.727 | 0.651 (0.059–7.230) | 0.773 | 0.697 (0.060–8.091) |
| CC | 1 | 2 | ||||
|
| ||||||
| rs7412 | ||||||
| Genotype | ||||||
| CC | 219 | 286 | 0.907 | 1.031 (0.619–1.717) | 0.873 | 1.049 (0.585–1.882) |
| CT | 30 | 38 | 0.790 | 1.306 (0.183–9.344) | 0.887 | 1.172 (0.132–10.400) |
| TT | 2 | 2 | ||||
|
| ||||||
| CLU | ||||||
| rs2279590 | ||||||
| Genotype | ||||||
| CC | 126 | 159 | 0.604 | 0.912 (0.644–1.292) | 0.298 | 0.807 (0.538–1.209) |
| CT | 99 | 137 | 0.760 | 1.094 (0.616–1.943) | 0.171 | 1.586 (0.819–3.071) |
| TT | 26 | 30 | ||||
|
| ||||||
| AFAP1 | ||||||
| rs11732100 | ||||||
| Genotype | ||||||
| CC | 162 | 208 | 0.678 | 0.927 (0.649–1.324) | 0.922 | 0.979 (0.650–1.477) |
| CT | 78 | 108 | 0.442 | 1.412 (0.585–3.407) | 0.576 | 0.711 (0.215–2.350) |
| TT | 11 | 10 | ||||
|
| ||||||
| TXNRD2 | ||||||
| rs35934224 | ||||||
| Genotype | ||||||
| CC | 203 | 252 | 0.118 | 0.709 (0.461–1.091) | 0.175 | 0.710 (0.433–1.165) |
| CT | 40 | 70 | 0.142 | 2.483 (0.737–8.362) | 0.258 | 2.245 (0.553–9.114) |
| TT | 8 | 4 | ||||
|
| ||||||
| CACNA1A | ||||||
| rs4926244 | ||||||
| Genotype | ||||||
| TT | 165 | 205 | 0.349 | 0.840 (0.584–1.209) | 0.224 | 0.774 (0.512–1.170) |
| TC | 71 | 105 | 0.684 | 1.165 (0.559–2.426) | 0.826 | 0.901 (0.356–2.282) |
| CC | 15 | 16 | ||||
|
| ||||||
| ABCA1 | ||||||
| rs2472493 | ||||||
| Genotype | ||||||
| AA | 91 | 115 | 0.713 | 0.934 (0.650–1.343) | 0.831 | 0.955 (0.626–1.457) |
| AG | 119 | 161 | 0.888 | 1.036 (0.631–1.702) | 0.906 | 0.966 (0.544–1.716) |
| GG | 41 | 50 | ||||
|
| ||||||
| LOXL1 | ||||||
| rs41435250 | ||||||
| Genotype | ||||||
| GG | 145 | 233 | 0.006 | 1.663 (1.158–2.388) | 0.071 | 1.478 (0.966–2.259) |
| GT | 89 | 86 | 0.003 | 3.902 (1.580–9.640) | 0.003 | 5.276 (1.748–15.930) |
| TT | 17 | 7 | ||||
|
| ||||||
| rs893818 | ||||||
| Genotype | ||||||
| GG | 171 | 154 | <0.001 | 0.511 (0.358–0.729) | <0.001 | 0.4449 (0.293–0.676) |
| GA | 76 | 134 | <0.001 | 0.095 (0.033–0.272) | <0.001 | 0.119 (0.039–0.356) |
| AA | 4 | 38 | ||||
|
| ||||||
| GAS7 | ||||||
| rs9897123 | ||||||
| Genotype | ||||||
| CC | 62 | 82 | 0.739 | 0.934 (0.625–1.396) | 0.440 | 0.833 (0.523–1.325) |
| CT | 125 | 177 | 0.335 | 1.263 (0.785–2.033) | 0.808 | 0.935 (0.542–1.612) |
| TT | 64 | 67 | ||||
|
| ||||||
| CNTNAP2 | ||||||
| rs2107856 | ||||||
| Genotype | ||||||
| GG | 89 | 117 | 0.917 | 1.02 (0.709–1.467) | 0.687 | 1.091 (0.715–1.665) |
| GT | 121 | 156 | 0.947 | 1.017 (0.622–1.664) | 0.537 | 1.194 (0.681–2.094) |
| TT | 41 | 53 | ||||
|
| ||||||
| rs2141388 | ||||||
| Genotype | ||||||
| CC | 91 | 118 | 0.981 | 0.996 (0.692–1.431) | 0.772 | 1.064 (0.698–1.624) |
| CT | 119 | 155 | 0.990 | 1.003 (0.614–1.639) | 0.570 | 1.177 (0.672–2.060) |
| TT | 41 | 53 | ||||
The genotypes AA for rs16958445 of TBC1D21 and GG/TT for rs41435250 of LOXL1 were risk genotypes for the disease. The genotypes CC for rs7137828 of ATXN2 and GG/AA for rs893818 of LOXL1 were protective genotypes for the disease.