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Irisin mediated the protection of dexmedetomidine against hepatic inflammation and oxidative stress injury. Effect of administration of irisin NA on (a) TNF-α, (b) IL-6, (c) MPO, (d) ROS, and (e) MDA levels and (f) SOD activity. The results were presented as the mean ± standard deviation (n = 8; ∗P < 0.05, ∗∗P < 0.01 vs. sham group; #P < 0.05; ##P < 0.01 vs. I/R group; &P < 0.05 vs. I/R+Dex group).
