Table 2.
Clinicopathological characteristics of BC cases with low and high levels of DNA repair capacity.
| Clinicopathological Characteristics | Low DRC (<3.8%) | High DRC (≥3.8%) | p-value |
|---|---|---|---|
| n=18 (%) | n=9 (%) | ||
| Estrogen receptor status | |||
| Positive | 9 (33.3) | 3 (11.1) | 0.5698 |
| Negative | 6 (22.2) | 3 (11.1) | |
| Missing | 3 (11.1) | 3 (11.1) | |
| Progesterone receptor status | |||
| Positive | 8 (29.6) | 3 (11.1) | 0.6121 |
| Negative | 7 (25.9) | 3 (11.1) | |
| Missing | 3 (11.1) | 3 (11.1) | |
| HER2 status | |||
| Positive | 0 (0.0) | 1 (3.7) | 0.7160 |
| Negative | 12 (44.4) | 5 (18.5) | |
| Missing | 6 (22.2) | 3 (11.1) | |
| Ki-67 | |||
| Low (≤10%) | 1 (3.7) | 1 (3.7) | 0.9297 |
| Borderline (11-20%) | 0 (0.0) | 0 (0.0) | |
| High (≥21%) | 3 (11.1) | 1 (3.7) | |
| Missing | 15 (55.6) | 6 (22.2) | |
| Grade | |||
| I | 4 (14.8) | 0 (0.0) | 0.4194 |
| II | 6 (22.2) | 4 (14.8) | |
| III | 5 (18.5) | 4 (14.8) | |
| Missing | 3 (11.1) | 1 (3.7) | |
| Molecular Subtypes | |||
| Luminal A | 7 (25.9) | 3 (11.1) | 0.6923 |
| Luminal B | 0 (0.0) | 0 (0.0) | |
| HER2+ | 0 (0.0) | 1 (3.7) | |
| Triple-negative | 5 (18.5) | 2 (7.4) | |
| Missing | 6 (22.2) | 3 (11.1) | |
| Site | |||
| Ductal | 16 (59.3) | 7 (25.9) | 0.3522 |
| Lobular | 2 (7.4) | 1 (3.7) | |
| Ductal + Lobular | 0 (0.0) | 1 (3.7) | |
| Type | |||
| In situ | 1 (3.7) | 0 (0.0) | 0.4712 |
| Invasive | 17 (63.0) | 9 (33.3) |
Pearson's chi-square test was performed to assess significance among groups.
DRC: DNA repair capacity, BMI: body mass index, BC: breast cancer.