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. 2019 May 5;2019:1845637. doi: 10.1155/2019/1845637

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Copyright © 2019 Juan Pellico et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a) Structure of the tobacco mosaic virus (TMV) nanoparticle's coat protein with surface-exposed residues highlighted as internal glutamic acid (blue) and external tyrosine (red) and the structure of the assembled capsid/strategy for internal modification. (b) Near-infrared fluorescence (NIRF) imaging of subcutaneous PC-3 (α2β1) prostate tumours in athymic nude mice (n = 3) before and 1, 6, and 24 h after the intravenous injection of Dy-Cy7.5-TMV-mPEG (control group) or Dy-Cy7.5-TMV-DGEA (targeting group). (c) In vivo T₂-mapping MRI of subcutaneous PC-3 (α2β1) prostate tumours in athymic nude mice (n = 3) obtained before and 1, 6, and 24 h after the intravenous injection of Dy-Cy7.5-TMV-mPEG (control group) and Dy-Cy7.5-TMV-DGEA (targeting group) (reprinted (adapted) with permission from [62]).