Table 1.
Summary of membrane and cytoskeletal targets of TCS.
| Model | Target | Response | |
|---|---|---|---|
| Gene/protein | Molecular identity | ||
| K. pneumoniae | KpnGH | Efflux pump | Sensitive to TCS |
|
| |||
| E. coli | AcrAB | Efflux pumps | Upregulated by TCS |
| acrE | Upregulated by TCS | ||
| mdtE | Upregulated by TCS | ||
| acrF | Upregulated by TCS | ||
| mdtB | Upregulated by TCS | ||
| mdtC | Upregulated by TCS | ||
| yddA | Upregulated by TCS | ||
| emrA | Upregulated by TCS | ||
| emrE | Upregulated by TCS | ||
| sanA | Cell wall/membrane structure | Upregulated by TCS | |
| dacB | Upregulated by TCS | ||
| amiC | Cell envelope | Upregulated by TCS | |
| clsA | Upregulated by TCS | ||
| ompX | Membrane porin | Downregulated by TCS | |
| motA | Flagellar | Upregulated by TCS | |
| flgM | Upregulated by TCS | ||
|
| |||
| R. rubrum S1H | sugE | Small multidrug resistance protein | Upregulated by TCS |
| mexF | RND efflux system, inner membrane transporter | Upregulated by TCS | |
| mexB | Upregulated by TCS | ||
| mexE | RND efflux system, membrane fusion proteins | Sensitive to TCS | |
| mexA | Upregulated by TCS | ||
| mexM | Upregulated by TCS | ||
| oprM | RND efflux system, outer membrane transporter | Upregulated by TCS | |
| glmM | Cell envelope; phosphoglucosamine mutase | Upregulated by TCS | |
| exoD | Cell envelope; exopolysaccharide synthesis protein D | Upregulated by TCS | |
| wbpM | Cell envelope; polysaccharide biosynthesis protein M | Upregulated by TCS | |
|
| |||
| A. tumefaciens C58 | AcrA | RND efflux system, periplasmic adaptor protein | Upregulated by TCS |
|
| |||
| Human erythrocytes | Na+,K+,Mg2+-ATPase | Membrane ion transporter | Sensitive to TCS |
|
| |||
| C. elegans | Pmp-3 | Membrane ABC transporter | Downregulated by TCS |
|
| |||
| D. rerio | Actin, cytoplasmic 2 | Cytoskeleton | Downregulated by TCS |
| Actin α1, skeletal muscle | Downregulated by TCS | ||
| Light polypeptide 3 | Downregulated by TCS | ||
| Desmin | Cytoskeleton; muscular filament structure | Upregulated by TCS | |
| Fast skeletal muscle myosin | Sensitive to TCS | ||
| Keratin, type I cytoskeletal 18 | Upregulated by TCS | ||
| Tropomyosin α-1 chain | Downregulated by TCS | ||
| Type II cytokeratin | Upregulated by TCS | ||
| Lamin B1 | Cytoskeleton; nuclear lamina | Downregulated by TCS | |
|
| |||
| D. polymorpha | Tubulin β-2/α-4 chain | Cytoskeleton | Upregulated by TCS |
| Tubulin β-4 chain | Upregulated by TCS | ||
| Myosin light chain | Cytoskeleton; muscular filament structure | Upregulated by TCS | |
Abbreviation: RND: resistance-nodulation-division; ABC: ATP-binding cassette.