Table 2.
Summary of cell survival molecules modulated by TCS.
| Model | Target | Response | |
|---|---|---|---|
| Gene/protein | Molecular identity | ||
| JEG-3 cells | Estradiol | Major female sex hormones | Upregulated by TCS |
| Progesterone | Upregulated by TCS | ||
| β-hCG | Maintenance of pregnancy | Downregulated by TCS | |
| Caspase-3 | Apoptosis regulator; proapoptotic | Upregulated by TCS | |
|
| |||
| BG-1 cells | Cyclin D1 | Cell cycle regulators | Upregulated by TCS |
| p21 | Downregulated by TCS | ||
| Bax | Apoptosis regulator; proapoptotic | Downregulated by TCS | |
|
| |||
| MCF-7 cells | Cyclin D1 | Cell cycle regulators | Upregulated by TCS |
| Cyclin E | Upregulated by TCS | ||
| p21 | Downregulated by TCS | ||
| Bax | Apoptosis regulator; proapoptotic | Downregulated by TCS | |
| Cathepsin B | Metastasis markers | Upregulated by TCS | |
| Cathepsin D | Upregulated by TCS | ||
| MMP-9 | Upregulated by TCS | ||
| MMP-2 | Upregulated by TCS | ||
| CXCR4 | Upregulated by TCS | ||
| Snail | Mesenchymal markers | Upregulated by TCS | |
| Slug | Upregulated by TCS | ||
|
| |||
| LNCaP | p21 | Cell cycle regulator | Downregulated by TCS |
|
| |||
| Primary human syncytiotrophoblasts | 11β-HSD2 | Fetal development; anticortisol | Downregulated by TCS |
| Caspase-3 | Apoptosis regulators; proapoptotic | Upregulated by TCS | |
| Bax | Upregulated by TCS | ||
| Bcl-2 | Apoptosis regulator; antiapoptotic | Downregulated by TCS | |
|
| |||
| Rat neural stem cells | Caspase-3 | Apoptosis regulators; proapoptotic | Upregulated by TCS |
| Bax | Upregulated by TCS | ||
| Bcl-2 | Apoptosis regulator; antiapoptotic | Downregulated by TCS | |
|
| |||
| Mouse neocortical neurons | GluN1 | Ionotropic glutamate receptors; neurotransmission | Downregulated by TCS |
| GluN1 | Downregulated by TCS | ||
| GluN2A | Downregulated by TCS | ||
| GluN2A | Downregulated by TCS | ||
| GluN2B | Upregulated by TCS | ||
| GluN2B | Downregulated by TCS | ||
| FasR | Apoptosis regulators; proapoptotic | Upregulated by TCS | |
| Caspase-8 | Upregulated by TCS | ||
| Caspase-9 | Upregulated by TCS | ||
| Caspase-3 | Upregulated by TCS | ||
| AhR | Ligand-activated receptor; detoxification | Upregulated by TCS | |
|
| |||
| JB6 Cl 41-5a cells | Cyclin D1 | Cell cycle regulators | Upregulated by TCS |
| Cyclin A | Upregulated by TCS | ||
| p27 | Downregulated by TCS | ||
|
| |||
| B6C3F1 mice | Alp | Pluripotency markers; stem cell self-renewal and differentiation regulators | Downregulated by TCS |
| Oct4 | Downregulated by TCS | ||
| Nanog | Downregulated by TCS | ||
| ALP | Downregulated by TCS | ||
| Oct 4 | Downregulated by TCS | ||
| Nanog | Downregulated by TCS | ||
| Sox 2 | Downregulated by TCS | ||
| miRNA-134 | Transcriptional regulator of pluripotency markers | Upregulated by TCS | |
|
| |||
| D. rerio | Oct4 | Pluripotency markers | Downregulated by TCS |
| Nanog | Downregulated by TCS | ||
| Sox2 | Upregulated by TCS | ||
| p53 | Cell cycle regulator; tumor suppressor | Upregulated by TCS | |
| Casp3 | Apoptosis regulators; proapoptotic | Upregulated by TCS | |
| Casp8 | Upregulated by TCS | ||
| Shha | Early neurogenesis | Sensitive to TCS sensitive to TCS | |
| Ngn1 | Upregulated by TCS | ||
| Nrd | Upregulated by TCS | ||
| Elavl3 | Upregulated by TCS | ||
| α1-tubulin | Neural maturation | Upregulated by TCS | |
| Gap43 | Upregulated by TCS | ||
| Gfap | Downregulated by TCS | ||
| Mbp | Downregulated by TCS | ||
Abbreviation: Shha: sonic hedgehog a; Ngn1: neurogenin 1; Nrd: NeuroD; Elavl3: ELAV-like, neuron-specific RNA-binding protein 3; Gap43: growth-associated protein 43; Gfap: glial fibrillary acidic protein; Mbp: myelin basic protein.