Table 2.
List of the pathways resulting from PANTHER database pathway overrepresentation analysis.
| PANTHER pathways | Homo sapiens—REFLIST (21042) | Client text box input (436)∗ | Client text box input (expected) | Client text box input (over/under) | Client text box input (fold enrichment) | Client text box input (raw P value) | Client text box input (FDR) |
|---|---|---|---|---|---|---|---|
| Pentose phosphate pathway (P02762) | 8 | 5 | 0.17 | + | 30.16 | 3.79E − 06 | 8.83E − 05 |
| Glycolysis (P00024) | 20 | 10 | 0.41 | + | 24.13 | 2.24E − 10 | 1.83E − 08 |
| ATP synthesis (P02721) | 7 | 3 | 0.15 | + | 20.68 | 8.96E − 04 | 1.62E − 02 |
| TCA cycle (P00051) | 10 | 3 | 0.21 | + | 14.48 | 2.04E − 03 | 2.56E − 02 |
| Plasminogen-activating cascade (P00050) | 18 | 4 | 0.37 | + | 10.72 | 9.17E − 04 | 1.49E − 02 |
| Blood coagulation (P00011) | 46 | 9 | 0.95 | + | 9.44 | 1.50E − 06 | 4.07E − 05 |
| Parkinson disease (P00049) | 103 | 16 | 2.13 | + | 7.5 | 2.52E − 09 | 1.37E − 07 |
| FAS signaling pathway (P00020) | 34 | 5 | 0.7 | + | 7.1 | 1.10E − 03 | 1.63E − 02 |
| Cytoskeletal regulation by Rho GTPase (P00016) | 84 | 12 | 1.74 | + | 6.89 | 5.64E − 07 | 1.84E − 05 |
| Huntington disease (P00029) | 145 | 17 | 3 | + | 5.66 | 3.59E − 08 | 1.46E − 06 |
| Dopamine receptor-mediated signaling pathway (P05912) | 58 | 6 | 1.2 | + | 4.99 | 1.88E − 03 | 2.55E − 02 |
| Integrin signalling pathway (P00034) | 190 | 14 | 3.94 | + | 3.56 | 7.78E − 05 | 1.59E − 03 |
| Unclassified (UNCLASSIFIED) | 18438 | 311 | 382.04 | — | 0.81 | 3.91E − 19 | 6.38E − 17 |
∗Referred to the experimental protein UniProt accession input list on PANTHER analysis tool.