Figure 3.

Regulation of the local immune response by CD73^high pMSC. The recruitment of immune cells in 5-day MI hearts was not altered by transplantation of either CD73^low or CD73^high pMSC (a). A subset of macrophages (CCR2⁺) was significantly diminished in amount in the CD73^high-treated hearts (b). Notably, CD73^high pMSC upregulated several anti-inflammatory-related genes (IL-4, IL-10, Arg-1, and TGM-2) and suppressed proinflammatory-related genes (TNF-α and NOS2). ^∗ indicates p < 0.05 and ^∗∗ indicates p < 0.01 compared to CD73^low-treated hearts.