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. 2019 May 18;16:106. doi: 10.1186/s12974-019-1490-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Depletion of microglia lowers IL1β mRNA and protein. Application of LPS to OHSCs results in a significant increase in IL1β protein in the culture medium (overall effect of LPS *p = 0.019) which is lowered in cultures pre-treated with clodronate (**p = 0.0025) (n = 5–6 per treatment group) (a). IL1β mRNA transcript is significantly upregulated in clodronate-naïve OHSCs after LPS treatment (*p = 0.02), but pre-treatment with clodronate lowers transcript levels to almost undetectable levels (****p < 0.0001) (n = 4–6 per treatment group) (b). Analysis was conducted using two-way ANOVA. Error bars = mean ± SEM