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. 2019 May 18;16:106. doi: 10.1186/s12974-019-1490-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Application of anti-IL1β-neutralising antibody alters the OHSC response to LPS. Western blot of antibody and LPS-treated cultures (a) shows that whilst OHSCs pre-treated with anti-βGAL (control) antibody show a reduction in synaptophysin when treated with LPS (*p = 0.02) cultures pre-treated with anti-IL1β-neutralising antibody are resistant to LPS addition (p = 0.83) (b). There is no significant rescue of synaptophysin levels when comparing control antibody +LPS and anti-IL1β antibody + LPS (p = 0.63). All analysis was conducted using a two-way ANOVA (n = 16 per treatment group). Error bars = mean ± SEM