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. 2019 Apr 13;9(9):2489–2504. doi: 10.7150/thno.31159

Figure 5.

Figure 5

Hemostatic effects of the intravenous administration of GS5-MOF nanoparticles. The cubic-shaped GS5-MOF nanoparticles possess a more efficient hemostatic effect than spherical GS5-NS and do not trigger unwanted thrombosis. (A) Experimental schematic of the mouse tail transection assay. (B) GS5-MOF nanoparticles significantly decrease bleeding time in a mouse tail transection model (n = 10). (C) GS5-MOF nanoparticles could reduce blood loss in a mouse tail transection model. (D) GS5-MOF nanoparticles significantly lower bleeding time in a rat femoral artery injury model (n = 6). (E) Pharmacokinetics of CL-MOF, GS5-MOF, and GS5-NS nanoparticles via tail vein injection in SD rats (n = 6). (F) Typical coagulation parameters of mice after injection of GS5-MOF nanoparticles at 40 mg·kg-1 (n = 6). The pink windows indicate the normal levels of different parameters. Data are presented as the mean ± SD (n = 6~10). *p < 0.05, ***p < 0.001.