Table 3.
Associations of hepatic panels and lipid biomarkers with adolescent weight status using logistic regression analysis
Parameters | NW | UW | P-value | OW | P-value | OB | P-value | OW+OB | P-value |
---|---|---|---|---|---|---|---|---|---|
BPS (mmHg) | 1 reference | 0.98 (0.96; 1.00) | 0.035 | 1.05 (1.03; 1.07) | 0.000 | 1.09 (1.07; 1.11) | 0.000 | 1.07 (1.06; 1.09) | 0.000 |
BPD (mmHg) | 1 reference | 1.03 (1.00; 1.06) | 0.048 | 1.05 (1.02; 1.07) | 0.000 | 1.06 (1.04; 1.09) | 0.000 | 1.06 (1.04; 1.08) | 0.000 |
Pulse | 1 reference | 1.01 (0.99; 1.03) | 0.479 | 1.02 (0.99; 1.03) | 0.067 | 1.01 (0.99; 1.02) | 0.353 | 1.01 (1.00; 1.03) | 0.069 |
TP (g/L) | 1 reference | 1.01 (0.96; 1.06) | 0.803 | 1.00 (0.96; 1.04) | 0.981 | 1.00 (0.96; 1.04) | 0.943 | 1.00 (0.97; 1.03) | 0.973 |
Albumin, Alb (g/L) | 1 reference | 1.01 (0.97; 1.05) | 0.569 | 0.93 (0.85; 1.01) | 0.058 | 0.88 (0.81; 0.95) | 0.001 | 0.90 (0.85; 0.96) | 0.001 |
ALT (U/L) | 1 reference | 0.90 (0.84; 0.97) | 0.004 | 1.06 (1.04; 1.09) | 0.000 | 1.13 (1.10; 1.06) | 0.000 | 1.10 (1.07; 1.12) | 0.000 |
AST (U/L) | 1 reference | 0.99 (0.92; 1.06) | 0.711 | 1.04 (0.99; 1.09) | 0.150 | 1.04 (1.08; 1.19) | 0.000 | 1.09 (1.05; 1.13) | 0.000 |
ALP (U/L) | 1 reference | 1.00 (1.00; 1.01) | 0.144 | 1.00 (0.99; 1.01) | 0.184 | 1.00 (0.99; 1.01) | 0.168 | 1.00 (0.99; 1.01) | 0.075 |
GGT (U/L) | 1 reference | 0.94 (0.89; 0.99) | 0.022 | 1.07 (1.04; 1.10) | 0.000 | 1.15 (1.11; 1.18) | 0.000 | 1.11 (1.08; 1.14) | 0.000 |
BChE (U/L) | 1 reference | 0.78 (0.63; 0.96) | 0.022 | 1.31 (1.10; 1.55) | 0.002 | 2.44 (1.97; 3.02) | 0.000 | 1.76 (1.52; 2.05) | 0.000 |
PA1 (g/L) | 1 reference | 0.02 (0.01; 10.72) | 0.230 | 2.45 (0.22; 27.83) | 0.470 | 12.73 (0.35; 466.56) | 0.166 | 180.44 (0.59; 576.92) | 0.097 |
BilT (mmol/L) | 1 reference | 1.02 (0.99; 1.06) | 0.175 | 1.00 (0.97; 1.03) | 0.957 | 0.99 (0.96; 1.02) | 0.396 | 0.99 (0.97; 1.11) | 0.603 |
CB (mmol/L) | 1 reference | 1.07 (0.97; 1.02) | 0.158 | 0.99 (0.91; 1.07) | 0.764 | 0.94 (0.86; 1.03) | 0.170 | 0.97 (0.90; 1.03) | 0.286 |
UCB (mmol/L) | 1 reference | 1.02 (0.98; 1.07) | 0.296 | 1.00 (0.96; 1.04) | 0.919 | 0.99 (0.94; 1.03) | 0.540 | 0.99 (0.96; 1.03) | 0.718 |
TBA (mmol/L) | 1 reference | 1.05 (0.95; 1.16) | 0.332 | 0.88 (0.77; 0.99) | 0.036 | 0.88 (0.77; 0.99) | 0.041 | 0.88 (0.80; 0.96) | 0.007 |
FPG (mmol/L) | 1 reference | 0.73 (0.41; 1.28) | 0.266 | 0.89 (0.56; 1.41) | 0.615 | 0.94 (0.59; 1.51) | 0.809 | 0.91 (0.63; 1.31) | 0.598 |
TG (mmol/L) | 1 reference | 0.98 (0.49; 1.95) | 0.952 | 1.15 (0.67; 1.97) | 0.623 | 4.49 (2.79; 7.23) | 0.000 | 2.51 (1.70; 3.72) | 0.000 |
TC (mmol/L) | 1 reference | 0.88 (0.59; 1.31) | 0.529 | 1.15 (0.85; 1.55) | 0.638 | 2.09 (1.54; 2.84) | 0.000 | 1.52 (1.20; 1.92) | 0.000 |
HDL-C (mmol/L) | 1 reference | 1.83 (0.73; 4.57) | 0.195 | 0.23 (0.10; 0.52) | 0.000 | 0.07 (0.03; 0.17) | 0.000 | 0.14 (0.07; 0.27) | 0.000 |
LDL-C (mmol/L) | 1 reference | 0.74 (0.46; 1.2) | 0.225 | 1.64 (1.15; 2.35) | 0.007 | 3.04 (2.08; 4.43) | 0.000 | 2.21 (1.65; 2.96) | 0.000 |
ApoA1 (g/L) | 1 reference | 1.79 (0.45; 7.14) | 0.410 | 0.09 (0.03; 0.33) | 0.000 | 0.20 (0.06; 0.69) | 0.011 | 0.15 (0.06; 0.40) | 0.000 |
ApoB (g/L) | 1 reference | 0.48 (0.08; 3.02) | 0.437 | 6.09 (1.83; 26.5) | 0.004 | 304.49 (64.8; 1430.81) | 0.000 | 47.79 (15.14; 150.87) | 0.000 |
Note: Multiple logistic regression analyses were performed and ORs (95% CIs) were showed with adjustment for age and gender.
Abbreviations: UW, underweight group; NW, normal weight group; OW, overweight group; OB, obese group; BMI, body mass index; WHR, waist-to-hip ratio; WHtR, waist-to-height ratio; BPS, systolic blood pressure; BPD, diastolic blood pressure; TP, total protein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; PA1, pre-albumin; BilT, total bilirubin; CB, conjugated bilirubin; UCB, un-conjugated bilirubin; TBA, total bile acid; FPG, fasting plasma glucose; TG, triglycerides; TC, total cholesterol; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; ApoA1, apolipoprotein A1; AopB, apolipoprotein B.