Table S4.

Health care resource utilization direct costs over 2 years after index date according to stage of diagnosis (late vs early)

	Early diagnosis, €	Late diagnosis, €
Drugs, respiratory (R03)	386.5	900.1
Drugs, other	460.8	716.6
Hospital nights, COPD (J45)	191.6	1,397.48
Hospital nights, not COPD	13,944.89	13,865.85
Hospital visits, COPD (J45)	15.0	56.25
Hospital visits, not COPD	1,410.0	1,777.5
Primary care contacts, physician	2,386.72	2,881.97
Primary care contacts, not physician	685.4	929.76

Notes: Costs were based on unit costs for hospital nights (9,580 SEK), hospital visits (3,000 SEK), primary care visits, physician (1,462 SEK) and primary care visits, nurse (596 SEK) and converted to Euros based on exchange rates in 2013 (8/1).

Abbreviations: COPD, chronic obstructive pulmonary disease; SEK, Swedish Krona; Hospital nights, number of nights where the patient has been at the hospital; hospital visit, outpatient care where the patient did not stay overnight at the hospital.