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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Free Radic Biol Med. 2019 Apr 13;137:37–45. doi: 10.1016/j.freeradbiomed.2019.04.013

Fig. 8.

Fig. 8.

Increased invasiveness of PDT-surviving cells: mitigation by a PI3K inhibitor, p300 inhibitor, or iNOS/NO inhibitor. PDT-challenged U87 cells, along with non-irradiated controls (DC), were harvested into serum-free medium lacking or containing the following inhibitors: LY294002 (LY, 20 μM), C646 (50 μM), GW274150 (GW, 75 μM)), or cPTIO (cP, 50 μM). The cells were transferred to the upper wells of a 96-place trans-well device and allowed to invade through Matrigel-infused filters toward 10% FBS-containing medium in the lower wells. After 24 h in the incubator, cells adhering to the filter undersides were centrifuged off into the lower wells and quantified in terms of live cell counts. Plotted data are means ± SD of values from 5 separate experiments; *P<0.01 vs. DC; **P<0.01 vs. PDT; #P<0.05 vs. PDT.