Table 3:

Typical Diffusion-Weighted Imaging (DWI) and Dynamic Contrast Enhanced (DCE) Acquisition Details for (A) Brain, (B) Prostate, (C) Breast, (D) Liver, and (E) Head and Neck

(A) BRAIN
Parameters	DWI		DCE
Field Strength	1.5 T/3T		1.5T/3T
Acquisition Sequence	SS-EPI		3D SPGR
Receive Coil type	≥8channel head array coil		≥8channel head array coil
Lipid Suppression	On		On
Slice thickness (mm)	4–5		≤5
Gap thickness (mm)	0–2		0–1
FOV(mm)	220 −240		220 −240
Acquisition Matrix	160–256 × 160–256 or 1.5–1 mm in plane resolution		256×128–160
Plane Orientation	Axial		Axial
Phase/frequency encode direction	AP/RL		AP/RL
Receiver bandwidth (Hz/pixel)	Max possible in freq encoding direction (acceptable > 1000)		250
	DWI Sequence Class Monopolar Bipolar Bipolar Double Spin Echo		Contrast*	Pre-	Post-
	# b-values	≥ 2 (including b=0 s/mm2)	# Phases	≥5	40–80
Specific Parameters	Minimum highest b-value (s/mm2)	850–1000	# Averages	≥1	1
	# Averages	≥2	Flip Angles (FAs) (deg)	2–30*	25–30
	Diffusion Directions	3 orthogonal	# Flip Angles (FAs)	2–7	1
	TR (ms)	3000–5000	TR (ms)	3–8¥	3–8
	TE (ms)	Minimum	TE (ms)	≤3¥	≤3
	In plane parallel imaging	2	Temporal Resolution (sec) /Total Acquisition Time (min)	<10 (ideal 5)/5–10
	Total Acquisition Time (min)	3	#Contrast Dose and IV injection rate see references *Variable FAs for T10 measurement ¥Ensure TR/TE stays constant for all flip angles

(B) PROSTATE
Parameters	DWT		DCE
Field Strength	3T		1.5T/3T
Acquisition Sequence	SS-EPI		3D SPGR
Receive Coil type	> 8 channel torso array coil; pelvic phase array/endorectal coils; body array coil)		> 8 channel torso array coil; pelvic phase array coil/endorectal coils; body array coil)
Lipid Suppression	On		NA
Slice thickness (mm)	3–5		<5
Gap thickness (mm)	0–1		0–1
FOV(mm)	240–260		260–300
Acquisition Matrix	224–128 × 224–128; 1–2 mm in-plane resolution		<256×l60
Plane Orientation	Axial		Axial
Phase/frequency encode direction	AP/RL		RL/AP
Receiver bandwidth (Hz/pixel)	Max possible in freq encoding direction (acceptable > 1000)		250
	DWI Sequence Class Monopolar Bipolar Bipolar Double Spin Echo		Contrast#	Pre-	Post-
	# b-values	2 (including b < 50–100 s/mm2)	# Phases	≥5	Sufficient to allow acquisition of at least 5 min post injection; ≥ 30
Specific Parameters	Minimum highest b-value (s/mm2)	500–1500	# Averages	≥1	1
	# Averages	2-≥4	Flip Angles (FAs) (deg)	2–15*	10–15
	Diffusion Directions	≥ 3 orthogonal	#Flip Angles (FAs)	3–5	1
	TR (ms)	≤4000	TR (ms)	<5¥	<5
	TE (ms)	Minimum	TE (ms)	≤2¥	≤2
	In plane parallel imaging	2	Temporal Resolution (sec) /Total Acquisition Time (min)	<10/5–10
	Total Acquisition Time (min)	3	#Contrast Dose and IV injection rate see references * Variable FAs for T10 measurement ¥Ensure TRITE stays constant for all flip angles

(C) BREAST
Parameters	DWI		DCE
Field Strength	1.5T/3T		1.5T/3T
Acquisition Sequence	SS-EPI/SE-EPI		3D SPGR
Receive Coil type	≥ 4 channel breast phase array coil		> 4 channel breast phase array coil
Lipid Suppression	On		On
Slice thickness (mm)	4–5		<2.5
Gap thickness (mm)	0–1		0
FOV(mm)	260–360		To cover the entire breast whether uni- or bilateral
Acquisition Matrix	128–192 × 128–192		> 192×256; 1–1.5 mm in-plane resolution
Plane Orientation	Axial		Sagittal for single breast coverage; axial for bi lateral coverage
Phase/frequency encode direction	RL/AP		RL/AP for axial bilateral; HF/AP for sagittal unilateral
Receiver bandwidth (Hz/pixel)	Max possible in freq encoding direction		250
	DWI Sequence Class Monopolar Bipolar Bipolar Double Spin Echo		Contrast#	Pre-	Post-
	# b-values	≥2	# Phases	≥2	Sufficient to allow acquisition for ≥ 8 min post injection
Specific Parameters	Minimum highest b-value (s/mm2)	800	# Averages	≥1	1
	# Averages	≥2	Flip Angle (FA) (deg)	2–30*	10–30
	Diffusion Directions	3 orthogonal	# Flip Angles (FAs)	3–5	1
	TR (ms)	≥4000	TR (ms)	<8¥	<8
	TE (ms)	Minimum	TE (ms)	≤3¥	≤3
	In plane parallel imaging	2	Temporal Resolution (sec) /Total Acquisition Time (min)	≤ 20 /≥8
	Total Acquisition Time (min)	4–6	* Contrast Dose and IV injection rate see references * Variable FAs for T10 measurement ¥ Ensure TR/TE stays constant for all flip angles

(D) LIVER
Parameters	DWI		DCE
Field Strength	1.5T/3T		1.5T/3T
Acquisition Sequence	SS-EPI		3D SPGR
Receive Coil type	> 6–16 channel torso array coil		> 8–32 channel flexible or AP body array coil
Lipid Suppression	On		On
Slice thickness (mm)	5–7		4–5
Gap thickness (mm)	0–1		0
FOV(mm)	300–450		280–380
Acquisition Matrix	160–196 × 160–192 or 2 −3 in-plane resolution		320 × (160–192)
Plane Orientation	Axial		Oblique
Phase/frequency encode direction	AP/RL		AP/RL
Receiver bandwidth (Hz/pixel)	Max possible in freq encoding direction (acceptable > 1000)		250
	DWI Sequence Class Monopolar Bipolar Bipolar Double Spin Echo		Contrast#	Pre-	Post-
	# b-values	≥2 (including one b = 50–100 s/mm2)	# Phases	≥5	100
Specific Parameters	Minimum highest b-value (s/mm2)	600–800	# Averages	≥2	1
	# Averages	2-≥4	Flip Angles (FAs) (deg)	2–30*	20–30
	Diffusion Directions	3 orthogonal	# Flip Angles (FAs)	3–5	1
	TR (ms)	>2000	TR (ms)	3–7¥	3–7
	TE (ms)	Minimum	TE (ms)	≤5¥	≤5
	In plane parallel imaging	2–3	Temporal Resolution (sec) /Total Acquisition Time (min)	< 5(ideal~3)/5
	Total Acquisition Time (min)	~5	# Contrast Dose and IV injection rate see reference * Variable FAs for T10 measurement ¥Ensure TR/TE stays constant for all flip angles

(E) HEAD AND NECK
Parameters	DWI		DCE
Field Strength	1.5T/3T		1.5 T/3T
Acquisition Sequence	SS-EPI		3D SPGR
Receive Coil type	Neck array or neurovascular coil		Neck array or neurovascular coil
Lipid Suppression	On		On
Slice thickness (mm)	≥5		>5
Gap thickness (mm)	0		0
FOV(mm)	220–380		180–220
Acquisition Matrix	128×128		256×128
Plane Orientation	Axial		Axial
Phase/frequency encode direction	AP/RL		RL/AP
Receiver bandwidth (Hz/pixel)	Max possible in freq encoding direction		250
	DWI Sequence Class Monopolar Bipolar Bipolar Double Spin Echo		Contrast#	Pre-	Post-
	# b-values	≥3	# Phases	≥5	40–80
Specific Parameters	Minimum highest b-value (s/mm2)	1000	# Averages	≥ 1	1
	# Averages	>2	Flip Angles (FAs) (deg)	5–30*	15–30
	Diffusion Directions	3 orthogonal	# Flip Angles (FAs)	≥3	1
	TR (ms)	≥2000	TR (ms)	<9¥	<9
	TE (ms)	Minimum	TE (ms)	<2¥	<2
	In plane parallel imaging	2	Temporal Resolution (sec) /Total Acquisition Time (min)	≤6/~5
	Total Acquisition Time (min)	3	#Contrast Dose and IV injection rate see references *Variable FAs for T10 measurement ¥Ensure TR/TE stays constant for all flip angles