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Sodium arsenite exposure affects the expression of genes, including tumor suppressor genes EP300 and Kif4. 2A and 2B showed up-regulated and downregulated genes after As exposure in MEF and Dot1L−/− cells. 2C and 2D showed qRT-PCR results using MEF and Dot1L−/− cells, respectively, for further validation. 2E and 2F showed Pearson correlation of results in two cell lines.
