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Sodium arsenite exposure inhibited histone acetyltransferase p300 and p300-mediated H3K27ac, as well as enhancer mark H3K4me1. 3A showed the expression of p300, and relative signals of H3K27ac and H3K4me1 in MEF and Dot1L−/− cells in different concentrations of As. 3B, 3C and 3D showed the quantitative results of p300, H3K27ac, and H3K4me1, respectively. *P < .05.
