Table 1.
Gene ontology analysis of DEGs associated with seminoma
| Expression | Category | Term | Count | % | P-value | FDR |
|---|---|---|---|---|---|---|
| Up-regulated | GOTERM_BP_FAT | Immune response | 206 | 36.20 | 6.12E−76 | 1.19E−72 |
| GOTERM_BP_FAT | Regulation of immune system process | 166 | 29.17 | 4.71E−53 | 9.19E−50 | |
| GOTERM_BP_FAT | Defense response | 168 | 29.53 | 1.39E−48 | 2.71E−45 | |
| GOTERM_BP_FAT | Positive regulation of immune system process | 130 | 22.85 | 4.61E−46 | 9.00E−43 | |
| GOTERM_BP_FAT | Regulation of immune response | 126 | 22.14 | 1.75E−45 | 3.41E−42 | |
| GOTERM_MF_FAT | Receptor binding | 112 | 19.68 | 1.01E−17 | 1.62E−14 | |
| GOTERM_MF_FAT | Signal transducer activity | 113 | 19.86 | 2.74E−12 | 4.42E−09 | |
| GOTERM_MF_FAT | Receptor activity | 104 | 18.28 | 2.08E−10 | 3.36E−07 | |
| GOTERM_MF_FAT | Molecular transducer activity | 104 | 18.28 | 2.08E−10 | 3.36E−07 | |
| GOTERM_MF_FAT | Protein complex binding | 61 | 10.72 | 3.30E−10 | 5.33E−07 | |
| GOTERM_CC_FAT | Intrinsic component of plasma membrane | 132 | 23.20 | 1.36E−19 | 2.02E−16 | |
| GOTERM_CC_FAT | Cell surface | 81 | 14.24 | 2.44E−19 | 3.60E−16 | |
| GOTERM_CC_FAT | Side of membrane | 60 | 10.54 | 2.75E−19 | 4.06E−16 | |
| GOTERM_CC_FAT | Integral component of plasma membrane | 128 | 22.50 | 2.89E−19 | 4.27E−16 | |
| GOTERM_CC_FAT | External side of plasma membrane | 44 | 7.73 | 8.94E−19 | 1.32E−15 | |
| Down-regulated | GOTERM_BP_FAT | Reproductive process | 145 | 19.03 | 9.16E−27 | 1.79E−23 |
| GOTERM_BP_FAT | Reproduction | 145 | 19.03 | 1.06E−26 | 2.08E−23 | |
| GOTERM_BP_FAT | Single organism reproductive process | 133 | 17.45 | 2.37E−25 | 4.63E−22 | |
| GOTERM_BP_FAT | Sexual reproduction | 98 | 12.86 | 1.32E−23 | 2.58E−20 | |
| GOTERM_BP_FAT | Multi-organism reproductive process | 107 | 14.04 | 4.11E−22 | 8.04E−19 | |
| GOTERM_MF_FAT | Kinase activity | 74 | 9.71 | 6.64E−08 | 1.08E−04 | |
| GOTERM_MF_FAT | Carbohydrate derivative binding | 141 | 18.50 | 2.01E−07 | 3.27E−04 | |
| GOTERM_MF_FAT | Protein serine/threonine kinase activity | 43 | 5.64 | 9.12E−07 | 1.49E−03 | |
| GOTERM_MF_FAT | Adenyl nucleotide binding | 103 | 13.52 | 1.06E−06 | 1.72E−03 | |
| GOTERM_MF_FAT | Adenyl ribonucleotide binding | 102 | 13.39 | 1.35E−06 | 2.20E−03 | |
| GOTERM_CC_FAT | Cilium | 55 | 7.22 | 1.78E−09 | 2.70E−06 | |
| GOTERM_CC_FAT | Neuron projection | 75 | 9.84 | 1.04E−06 | 1.58E−03 | |
| GOTERM_CC_FAT | Ciliary part | 37 | 4.86 | 1.40E−06 | 2.12E−03 | |
| GOTERM_CC_FAT | Cytosol | 196 | 25.72 | 5.46E−06 | 8.26E−03 | |
| GOTERM_CC_FAT | Neuron part | 92 | 12.07 | 7.43E−06 | 1.12E−02 |