Table 2.

Association between clinicopathologic parameters/SII and OS in TNBC

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P-value	HR (95% CI)	P-value
Age (years)
≤35	1		/
>35	0.86 (0.52–1.4)	0.552	/	/
T stage
pT1	1		1
pT2–4	1.99 (1.26–3.14)	0.003	1.72 (1.04–2.86)	0.035
Pathology
Invasive ductal carcinoma	1		/
Invasive lobular carcinoma	0.95 (0.92–1.01)	0.723	/	/
Tumor differentiation
G1–2	1		1
G3	3.06 (2.09–4.49)	<0.001	2.02 (1.34–3.06)	0.001
Ki-67
≤30%	1		1
>30%	2.87 (1.98–3.79)	<0.001	1.96 (1.27–2.81)	0.006
Chemotherapy
Adjuvant	1		/
Neoadjuvant	0.9 3(0.67–1.26)	0.468	/	/
Adjuvant radiotherapy
Yes	1		/
No	1.24 (0.81–1.52)	0.356	/	/
Type of surgery
Breast-conserving surgery	1		1
Radical mastectomy	2.69 (1.56–4.65)	<0.001	2.54 (1.46–4.42)	0.001
N stage
pN0	1		1
pN1–3	1.67 (1.15–2.43)	0.006	1.04 (0.70–1.56)	0.820
SII
≤557	1		1
>557	2.91 (2.00–4.23)	<0.001	2.60 (1.74–3.88)	<0.001

Abbreviations: TNBC, triple-negative breast cancer; SII, systemic immune-inflammation index; OS, overall survival.