Table 4.
Association between clinicopathologic parameters/SII and DMFS in TNBC
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Age (years) | ||||
| ≤35 | 1 | 1 | ||
| >35 | 0.61 (0.41–0.92) | 0.020 | 0.72 (0.47–1.11) | 0.142 |
| T stage | ||||
| pT1 | 1 | 1 | ||
| pT2–4 | 2.94 (1.81–4.78) | <0.001 | 2.32 (1.38–3.89) | 0.001 |
| Pathology | ||||
| Invasive ductal carcinoma | 1 | / | ||
| Invasive lobular carcinoma | 0.96 (0.95–1.01) | 0.756 | / | / |
| Tumor differentiation | ||||
| G1–2 | 1 | 1 | ||
| G3 | 3.14 (2.13–4.62) | <0.001 | 2.34 (1.49–3.66) | <0.001 |
| Ki-67 | ||||
| ≤30% | 1 | 1 | ||
| >30% | 2.21 (1.62–2.91) | <0.001 | 1.89 (1.34–2.61) | 0.007 |
| Chemotherapy | ||||
| Adjuvant | 1 | / | ||
| Neoadjuvant | 0.92 (0.49–1.51) | 0.824 | / | / |
| Adjuvant radiotherapy | ||||
| Yes | 1 | / | ||
| No | 1.19 (0.71–1.96) | 0.637 | / | / |
| Type of surgery | ||||
| Breast-conserving surgery | 1 | / | ||
| Radical mastectomy | 1.53 (0.84–2.78) | 0.157 | / | / |
| N stage | ||||
| pN0 | 1 | 1 | ||
| pN1–3 | 2.14 (1.49–3.07) | <0.001 | 1.16 (0.75–1.81) | 0.485 |
| SII | ||||
| ≤557 | 1 | 1 | ||
| >557 | 1.81 (1.28–2.55) | 0.001 | 1.40 (0.96–2.03) | 0.078 |
Abbreviations: TNBC, triple-negative breast cancer; SII, systemic immune-inflammation index; DMFS, distant metastasis-free survival.