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. 2019 Apr;7(8):170. doi: 10.21037/atm.2019.03.40

Figure 1.

Figure 1

Expression of pyroptosis-associated proteins increased in both human and murine osteomyelitis accompanied by bone destruction in murine model. (A) The expression of NLRP3, GSDMD, caspase3 and RIP3 between normal patients and osteomyelitis patients were detected by western blot (n=3 in each group, 2 randomly selected samples in each group); (B) quantification of Figure 1A; (C) reconstructed sectional images of trabecular bone and cortical bone; (D) serum concentration of CRP; (E) the expression of NLRP3, GSDMD and caspase1 in Sham surgery bone and bacterial infected bone both 3 and 7 days after surgery were examined by western blot (n=6 in each group, 2 randomly selected samples in each group); (F) quantification of Figure 1C; *, P<0.05. CRP, C-reactive protein.