Table 1:

Linear regression models assessing the effect of HIV-1 subtype, socio-demographic and clinical factors on Nef-mediated inhibition of NFAT signalling.

Variable		Univariate (TCR)		Multivariable (TCR)a
		Estimate	p-value	Estimate	p-value
Subtype	A	−0.099	0.02	−0.10	0.01
	B	0	N/A	0	N/A
	C	−0.162	0.0001	−0.15	0.0007
	D	0.035	0.4	0.03	0.49
Log viral load		0.032	0.1	-	-
Log CD4		−0.084	0.02	−0.04	0.25
Male		0.040	0.2	-	-
Age		−0.001	0.5	-	-

CD4 counts and viral load estimates are expressed per log₁₀ increment. Age is expressed per year increment.

Female was the reference group for gender. Subtype B was the reference group for HIV-1 subtypes.

^aMultivariable model for Nef’s inhibition of TCR-mediated NFAT signalling: multiple r² = 0.079, p = 0.00002.