Table 3:

Linear regression models assessing the effect of Nef-mediated inhibition of NFAT signalling on rate of CD4 decline

Variable	Univariate		Multivariablea
	Estimate	p-value	Estimate	p-value
NFAT inhibition	−3.68	0.26	−2.91	0.31
Square-root baseline CD4+ count	−0.47	0.006	−0.88	0.0001
Follow-up time	0.003	0.009	0.01	<0.0001
Log baseline viral load	0.4	0.57	−0.37	0.61

CD4+ counts are expressed per one square root unit increase and viral load estimates are expressed per log10 increment. Follow-up time is expressed per day increment.

^aMultivariable model for rate of CD4+ T cell decline: multiple r² = 0.27, p < 0.00001.