Figure 1.

In (A), current schizophrenia is represented, including several entities with positive symptoms, without a biological underpinning for the diagnosis. In (B), schizophrenia is represented by the schizophrenia continuum, 2, in which negative and cognitive deficits are core aspects of the disorder–neurodevelopmental psychosis. Area 3 represents other psychotic processes in which positive symptoms are core aspects instead—including the concepts of non-deficit schizophrenia and neurodegenerative psychosis. Accordingly, individuals at ultra-high risk for psychosis would be distinguished between those with cognitive decline and subtle negative symptoms (UHR 1—worst outcome) and those without such deterioration (UHR 2—more benign outcome). Area 1 would represent the subclinical symptom spectrum, with increased interchange and blending between symptom dimensions. (Blending of dimensions, e.g., schizoaffective disorder, is not represented in this scheme).