Table 3.
Results of histological analysis according to the histological scoring system for NAFLD
| ITEM | DEFINITION | SCORE | PERCENTAGE FOR GROUP | P | ||
|---|---|---|---|---|---|---|
|
| ||||||
| Placebo | Ramipril | Control | ||||
| Steatosis | < 5% | 0 | 0% | 10% | 100% | 0.032 |
| Grade | 5 a 33% | 1 | 0% | 40% | ||
| > 33 a 66% | 2 | 50% | 40% | |||
| > 66% | 3 | 50% | 10% | |||
| Lobular | No foci | 0 | 0% | 0% | 100% | 0.006 |
| Inflammation | < 2 foci per 200X field | 1 | 20% | 90% | ||
| 2-4 foci per 200X field | 2 | 40% | 10% | |||
| > 4 foci per 200X field | 3 | 40% | 0% | |||
| Hepatocellular | None | 0 | 0% | 10% | 100% | 0.023 |
| Balooning | Few balloon cells | 1 | 20% | 70% | ||
| Many cells/prominent ballooning | 2 | 80% | 20% | |||
| Fibrosis Stage | None | 0 | 0% | 0% | 100% | 0.020 |
| Perisinusoidal or periportal | 1 | 0% | 0% | |||
| Mild, zone 3, perisinusoidal | 1A | 20% | 60% | |||
| Moderate, zone 3, perisinusoidal | 1B | 10% | 30% | |||
| Portal/periportal | 1C | 50% | 10% | |||
| Perisinusoidal and portal/periportal | 2 | 20% | 0% | |||
| NAS | Not NASH | 0-2 | 0% | 20% | 100% | 0.003 |
| Borderline | 3-4 | 0% | 50% | |||
| NASH | ≥ 5 | 100% | 30% | |||
NAS, nonalcoholic fatty liver disease activity score; NASH, nonalcoholic steatohepatitis. p, p value: placebo vs ramipril (Fisher’s exact test, after grouping the scores into two categories).