Comparison 7. Imipramine (TCA) versus sertraline (SSRI).

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Relapse/recurrence	1	376	Risk Ratio (M‐H, Random, 95% CI)	1.27 [0.84, 1.91]
2 Dropout due to any reason	1	386	Risk Ratio (M‐H, Random, 95% CI)	0.81 [0.48, 1.38]
3 Depression severity	1	377	Mean Difference (IV, Random, 95% CI)	0.40 [‐0.97, 1.77]
4 Health‐related quality of life	1	347	Mean Difference (IV, Random, 95% CI)	‐4.30 [‐7.31, ‐1.29]
5 Dropout due to any type of adverse event	1	386	Odds Ratio (M‐H, Random, 95% CI)	1.99 [0.60, 6.65]