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. 2019 May 20;2019(5):CD012855. doi: 10.1002/14651858.CD012855.pub2

Kocsis 1995.

Methods Design: NRCT
Phases: acute (6–10 weeks), continuation (16–20 weeks), maintenance (104.4 weeks)
Comparison groups: imipramine vs desipramine
Funded by: no information
Participants Number of participants randomized (NRCT: number of participants included): 73
Criteria for relapse/recurrence: no information; this outcome was not addressed.
Age distribution in sample (mean): 36.0 (SD 10.0) years
Sex distribution in sample (% women): 64.1
Diagnoses in sample: 37.0% dysthymia, 63.0% double depression
Depression severity at continuation/maintenance baseline: unclear
Age of onset: unclear
Length current/last major episode in months: unclear
Interventions Continuation treatment (16–20 weeks)
Imipramine (participants = 23)
Name (class and type): imipramine (TCA)
Planned dosage of drug: 300 mg/day
Dosage of drug: unclear
Sertraline (participants = 50)
Name (class and type): desipramine (TCA)
Planned dosage of drug: 200 mg/day
Dosage of drug (mean): 232 (SD 72) mg/day
Notes: "Patients were allowed to remain in stable long‐term psychotherapy during the study but were not allowed to enter into new psychotherapy arrangements." (p. 214) No data provided about the percentage of participants receiving parallel psychotherapy. "Concomitant psychotropic medications were proscribed." (p. 214)
Outcomes Dropout any
Dropout due to adverse event
Notes There were 3 different treatment arms in the acute treatment, but it was unclear how participants were allocated to the different treatment arms, e.g. if there were randomized. Additionally, the rationale of the acute treatment was unclear (e.g. some participants received medication on a double blind and some on an open basis).