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. 2019 May;58(3):373–379. doi: 10.30802/AALAS-JAALAS-18-000094

Figure 1.

Figure 1.

(A) Time to LORR and (B) time to death after a euthanizing dose of sodium pentobarbital given intraperitoneally to mice. The 5- and 50-mg/mL solutions were given at 250 mg/kg, whereas the 390-mg/mL solution was given at a uniform volume of 0.1 mL per mouse (that is, approximately 1680 mg/kg in female mice and 1300 mg/kg in male). (A) Time to LORR showed a significant (*, P = 0.0489; ‡, P < 0.0001; ANOVA with Box–Cox transformation to normalize data) treatment effect. (B) Time to death showed a significant (‡, P < 0.0001; ANOVA with Box–Cox transformation to normalize data) dose effect but no significant difference between the 5-and 50-mg/mL solutions. Bars indicate 95% CI.