Table 3.

Mean mid-metatarsal dorsopedal paw diameter (cm) of control compared with injected paws

		Randomized group 1										Randomized group 2
		Sterile water			5 mg/mL			50 mg/mL			Saline			390 mg/mL
Straina	Sexb	Cont	Treat	% diff	Cont	Treat	% diff	Cont	Treata–e	% diff	Cont	Treat	% diff	Cont	Treatf,g	% diff
C57BL/6	Male	0.218	0.232	6.3	0.202	0.217	7.3	0.205	0.282	31.6	0.228	0.232	2.0	0.248	0.300	18.7
	Female	0.195	0.206	5.4	0.187	0.196	4.2	0.187	0.264	33.8	0.232	0.231	−0.7	0.233	0.330	34.7
											0.316	0.323	2.1	0.319	0.400	22.6
CD1	Male	0.313	0.324	3.4	0.302	0.324	6.8	0.311	0.327	4.9	0.291	0.298	2.2	0.288	0.366	24.0
	Female	0.208	0.229	9.3	0.213	0.229	7.5	0.220	0.298	30.2	0.228	0.232	2.0	0.248	0.300	18.7

Cont, control; Treat, treated

Percentage difference (% diff) was calculated as [(mean diameter_treated – mean diameter_control) / (average mean of treated and control)] x 100%.

^aSignificant (P < 0.0001) difference in paw diameter between strains

^bSignificant (P < 0.0001) difference in paw diameter between sexes

^cSignificant (P < 0.0001) difference in mean paw diameter between 50-mg/mL and sterile water groups

^dSignificant (P < 0.0001) difference in mean paw diameter between 5- and 50-mg/mL groups

^eSignificant (P < 0.0001) difference in mean paw diameter between control and treated paws for 50-mg/mL groups

^fSignificant (P < 0.0001) difference in mean paw diameter between 390 mg/mL-treated paw and 0.9% saline-treated paws

^gSignificant (P < 0.0001) difference in mean paw diameter between control and treated paws for the 390-mg/mL group