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. 2019 May;189(5):1077–1090. doi: 10.1016/j.ajpath.2019.01.016

Figure 1.

Figure 1

Blockade of Yap-mediated transcriptional regulation via dnTEAD2 suppresses hepatoblastoma growth in mice. A: Study design. B: Survival curve of Yap/β-catenin/pT3 and Yap/β-catenin/dnTEAD2 mice. C: Gross images, hematoxylin and eosin (H&E) staining, and Ki-67 immunohistochemistry of Yap/β-catenin/pT3 and Yap/β-catenin/dnTEAD2 mouse livers at 10.7 and 17 weeks after hydrodynamic injection, respectively. Arrows indicate the proliferation activity of hepatocytes. n = 5 Yap/β-catenin/pT3 and Yap/β-catenin/dnTEAD2 mice (B). Scale bar = 100 μm (C, middle and right columns). Original magnification, ×100 (C). SL, surrounding liver tissues; T, tumor tissues.