Figure 8.

Silencing of TEAD4 decreases proliferation and augments apoptosis in hepatoblastoma (HB) cell lines. HepG2 (A) and Hep293TT (B) human HB cell lines were transfected with scrambled siRNA (siSC), small interfering (si) TEAD1, siTEAD2, siTEAD3, or siTEAD4. Cell proliferation and apoptosis were measured. Untreated cells cultured in serum-free medium for 24 hours were used as baseline (ie, 1), and all cell proliferation and apoptosis rates were normalized to the baseline values. Data are expressed as means ± SD (A and B). n = 5 independent replicates (A and B). ^∗P < 0.05, ^∗∗P < 0.01, and ^∗∗∗P < 0.001 when compared with siSC (U-test).