Effect of 1 on the replicative lifespan of K6001 (a) and the chronological lifespan of YOM36 (b) yeast strains. The average lifespan of K6001 was as follows: control, 7.35 ± 0.44; Res at 10 μM, 10.57±0.67∗∗; and 1 at 0.1 μM, 8.78 ± 0.64; at 1 μM, 9.93 ± 0.62∗; at 3 μM, 10.13±0.65∗∗; and at 10 μM, 9.69 ± 0.61∗. Each experiment was repeated thrice, and the results were expressed as mean ± SEM. ∗ and ∗∗ indicate a significant difference relative to the control (P < 0.05 and P < 0.01). The days at which viability is equal to 0 of YOM36 after treatment with 1 were as follows: control, 11 days; 1 at 1 μM, 11 days; and 1 at 3 μM, 17 days.