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(a, b) IELLQAR inhibited monocyte activation by P-selectin-dependent activation of the PI3K/Akt/mTOR pathways. PBMCs were treated as described in Figure 6, and the expression levels of total and phosphorylated PI3K P85, Akt, and mTOR were determined by Western blot. Data are presented as the mean ± SEM (n = 3). ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001.
