Fig. 4.

Histopathologic examination of paw tissue of rats treated with maprotiline, 4 h after subplantar injection of carrageenan. A) Carrageenan-injected paw tissue in the vehicle-treated group. Migration of leukocytes mainly neutrophils and vasodilatation with edema were detected. B) Carrageenan-injected paw tissue of rats treated with maprotiline (25 mg/kg, i.p.). The migration of PMN leukocytes was reduced in a limited way. C) Carrageenan-injected paw tissue of rats treated with maprotiline (50 mg/kg, i.p.). The infiltration of PMN and edema was noticeably reduced. D) Carrageenan-injected paw tissue of rats treated with dexamethasone (1 mg/kg, i.p.). The PMN infiltration and edema was reduced considerably as compared with the vehicle-treated group. Sections were stained with hematoxylin and eosin, magnification ×40