Table 2.

Diagnostic criteria for DRESS syndrome [3]

Borquet et al.	RegiSCAR study group	Japanese consensus group
DRESS is confirmed by presence of 1 and 2 and 3 Cutaneous drug eruption Adenopathies > 2 cm in diameter of hepatitis (liver transaminases > 2 times upper limit of normal) (or) interstitial nephritis (or) interstitial pneumonitis (or) carditis Haematological abnormalities; eosinophilia > 1.5 × 109/l (or) atypical lymphocytes	More than 3 of the criteria are required for the diagnosis of DRESS Hospitalisation Reaction suspected to be drug related Acute rash Fever above 38°C Enlarged lymph nodes involving at least two sites Involvement of at least one internal organ Blood count abnormalities Lymphocytes above or below laboratory limits Eosinophils above laboratory limits (in percentage or absolute count) Platelets below laboratory limits	Typical DRESS (presence of all 7 criteria): atypical DIHS (all criteria present except lymphadenopathy and HHV-6 reactivation) HHV-6 reactivation Prolonged clinical symptoms 2 weeks after discontinuation of causative drug Maculopapular rash developing > 3 weeks after starting drug Fever above 38°C Lymphadenopathy ALT > 100 U/l or other organ involvement Leukocyte abnormalities (at least one) Leucocytosis (> 11 × 109/l) Atypical lymphocytosis (> 5%)Eosinophilia (1.5 × 109/l)

DRESS – drug rash with eosinophilia and systemic symptoms, RegiSCAR – European registry of severe cutaneous adverse reactions, DIHS – drug-induced hypersensitivity syndrome, HHV-6 – human herpesvirus 6, ALT – alanine aminotransferase