Table 2.
Summary of neonatal P0 mouse brain inoculation studies
| Type of Inoculums | Mouse Line Injected | ||
|---|---|---|---|
| M83+/− | M20+/− | nTg | |
| MSA Case 1 | 6/12 | 0/5 | 0/4 |
| MSA Case 2 | 3/12 | 0/8 | 0/6 |
| Control Case 1 | 0/8 | 0/4 | 0/4 |
| Control Case 2 | 0/8 | 0/16 | 0/11 |
| PBS | 0/20 | 0/5 | 0/6 |
| WT αS Fibrils | 5/5 | ||
| A53T αS Fibrils | 8/8 | ||
Number of mice with induced αS inclusion pathology per total number of mice injected for each cohort. Mouse lines: M83+/− and M20+/− transgenic mice and nTg mice. Inoculums: white matter cerebellum extracts from MSA or control individuals, PBS or in vitro aggregated recombinant WT or A53T human αS proteins