Figure 1.

STING stimulation with the cGAMP analogue 3′3′‐cAIMP induced the production of human chemotaxis‐related proteins in humanized mice. (a, b) Forest plot presentations of log2 fold changes in 72 analytes detected with Olink technology. Serum samples were collected for this analysis 6 hr following cAIMP dosing of Low‐Hu (a; n = 3) and Hi‐Hu (b; n = 3) mice. The forest plots incorporate non‐treated control (n = 3, Low‐Hu; n = 2, Hi‐Hu) values into the data presentation as the basis for the grey ‘no change’ bar that bisects the graphs from top to bottom reflects. The log2 fold change presented is interpreted as upregulated if the 90% confidence interval presented for each analyte is outside the bounds of the −1 to 1 interval highlighted by the grey bar. Confidence intervals in the forest plot span from 5% to 95%. Serum from cAIMP‐treated (6 hr) non‐humanized NOG mice was also analysed, and analytes that were positive in the non‐humanized mice were excluded such that the reported analyte concentrations reflect the levels of human molecules.