Figure 4.

Functional human type I interferon (IFN) production improved with STING expression. (a) Bioassay results for functional type I IFN levels in serum are shown. Mann–Whitney U‐test comparisons that met the alpha of 0·05 are noted with P‐values above the data within the figure. Each symbol represents one humanized NOG mouse. (b, c) Western blot analyses are shown for STING protein as well as for vinculin (VCL) expression in splenocytes and lung cells from humanized NOG mice. Each lower‐case letter label identifies a unique mouse. Group inclusion and treatment protocols for each animal are also noted.