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Effects of bromelain (BR) on expression of apoptosis regulators. Ca9‐22 and SCC25 cells were treated with different concentrations of BR for 24 hr. (A) Expression of p53, cytochrome‐C, and AIF, and (B) ICAD (DFF45) determined by Western blot analysis. AIF: apoptosis‐inducing factor; ICAD: inhibitor of caspase‐activated DNase
