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. 2019 May 20;7:79. doi: 10.1186/s40478-019-0726-2

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Immunohistochemical detection of huntingtin (HTT) in mouse brain. HTT is highly enriched in cholinergic striatal neurons (CPu), cholinergic neurons of the basal forebrain including medial septum (MS), vertical and horizontal diagonal band (VDB/HDB) and nucleus basalis magnocellularis (Nbm) as well as in cholinergic neurons of the olfactory tubercle (Tu), ventral pallidum (VP), and amygdala (Amy). At more caudal coronal brain levels, distinct HTT immunoreactivity present in cholinergic (oculomotor nerve nucleus; 3) and in urocortin-1 positive neurons of the Edinger-Westphal nucleus (EWN), pedunculopontine tegmental nucleus (PPT), laterodorsal tegmental nucleus (LDT), motor trigeminal nucleus (Mo5), nucleus abducens (6), nucleus facialis (7) and perifacial zone (P7), the parvicellular medial vestibular nucleus (MVePC), nucleus vagus (10), the hypoglossal nucleus (12) and nucleus ambiguus (Amb)

Fig. 2 — Immunohistochemical detection of huntingtin (HTT) in mouse brain. HTT is highly enriched in cholinergic striatal neurons (CPu), cholinergic neurons of the basal forebrain including medial septum (MS), vertical and horizontal diagonal band (VDB/HDB) and nucleus basalis magnocellularis (Nbm) as well as in cholinergic neurons of the olfactory tubercle (Tu), ventral pallidum (VP), and amygdala (Amy). At more caudal coronal brain levels, distinct HTT immunoreactivity present in cholinergic (oculomotor nerve nucleus; 3) and in urocortin-1 positive neurons of the Edinger-Westphal nucleus (EWN), pedunculopontine tegmental nucleus (PPT), laterodorsal tegmental nucleus (LDT), motor trigeminal nucleus (Mo5), nucleus abducens (6), nucleus facialis (7) and perifacial zone (P7), the parvicellular medial vestibular nucleus (MVePC), nucleus vagus (10), the hypoglossal nucleus (12) and nucleus ambiguus (Amb)