Table 1.

Covalent regulation of NLRP3 activation by phosphate groups: the identified phosphorylation sites on the NLRP3 protein that regulate its activity and the enzymes which are responsible for catalyzing the phosphorylation or dephosphorylation events. These enzymes may serve as potential targets to decrease the activity of the NLRP3 inflammasome in autoinflammatory and neuroinflammatory conditions.

Residue	Enzyme	Effect
Serine 5	Phosphatase 2a (Stutz et al., 2017)	Dephosphorylation→Inflammasome Assembly
Serine 194	JNK (Song et al., 2017)	Phosphorylation→NLRP3 BRRC3 Deubiquitination
Serine 295	PKA (Mortimer et al., 2016)	Phosphorylation→Inhibits Inflammasome Activity
Tyrosine 861	PTPN22 (Spalinger et al., 2016)	Phosphorylation→Inhibits Inflammasome Assembly
Tyrosine 918	Lyn (Lin et al., 2017)	Phosphorylation→NLRP3 Ubiquitinase/Degradation