Table 2.

NLRP3 activated cytokines and other major cytokines in psychiatric disorders: a list of inflammatory cytokines in the NLRP3 priming pathway sampled in patients with major depressive disorder and bipolar disorder.

Psychiatric Disorder	Inflammatory Protein (+/−)	Sample-Type	Source
Major Depressive Disorder	(+) Il-1β	CSF	(Levine et al., 1999)
	(+) Il-1β	Serum	(Anisman et al., 1999; Howren et al., 2009; Maes et al., 1993; Owen et al., 2001; Thomas et al., 2005)
	(+) IL-18	Serum	(Kokai et al., 2002; Merendino et al., 2002),
	(+) Il-6	Serum	(Howren et al., 2009; Lanquillon et al., 2000; Sluzewska, 1999)
	(−) Il-6	CSF	(Levine et al., 1999)
	(+) TNF-α	Serum	(Anisman et al., 1999; Hestad et al., 2003; Lanquillon et al., 2000)
Bipolar Disorder	(+) IL-1β	Post-Mortem Tissue	(Rao et al., 2010)