Table 1:

Known gene targets of individual activity-dependent TFs.

TF	Target gene	References
CREB	BDNF	Tao et al., 1998; Lonze and Ginty, 2002; Suzuki et al., 2011
	c-fos	Sheng and Greenberg, 1990; Sheng et al., 1990; Bito et al., 1996; Suzuki et al., 2011
	VMAT	Lonze and Ginty, 2002
	C/EBP	Lonze and Ginty, 2002
	iNOS/nNOS	Lonze and Ginty, 2002
	Egr1	Lonze and Ginty, 2002
	JunD	Lonze and Ginty, 2002
	TrkB	Lonze and Ginty, 2002
	α1-GABAAR	Lonze and Ginty, 2002
	Nurr1	Lonze and Ginty, 2002
	SGK	Lonze and Ginty, 2002
	Cdk5	Mayr and Montminy, 2001
	somatostatin	Montminy and Bilezikjian, 1987; Bito et al., 1996; Lonze and Ginty, 2002
Elk-1	c-fos	Hipskind et al., 1991;Janknechtand Nordheim, 1996; Cesari et al., 2004
	pip92	Latinkic et al., 1996
SRF	MAP1B	LI et al., 2014
	Arc	Ramanan et al., 2005; Etkin et al., 2006; Knöll and Nordheim, 2009; Stritt and Knöll, 2010; Li et al., 2014
	c-fos	Treisman, 1987; Ramanan et al., 2005; Etkin et al., 2006; Stritt and Knöll, 2010
	BDNF	Etkin et al., 2006; Knöll et al., 2006
	FosB	Ramanan et al., 2005; Etkin et al., 2006
	NGF	Etkin et al., 2006
	Nurr1	Etkin et al., 2006
	Egr1	Ramanan et al., 2005; Etkin et al., 2006; Stritt and Knöll, 2010; LI et al., 2014
	c-jun	Etkin et al., 2006
	clathrin heavy chain	Etkin et al., 2006
	Cdk5	Etkin et al., 2006
	P35	Etkin et al., 2006
	Inh1	Etkin et al., 2006
	IP3R1	Etkin et al., 2006
	RyR1	Etkin et al., 2006
	RyR3	Etkin et al., 2006
	Sema3c	Knöll et al., 2006; Knöll and Nordheim, 2009
	Actin, Actal, Actb, Actg2	Ramanan et al., 2005; Knöll et al., 2006; Miano et al., 2007; Knöll and Nordheim, 2009; Stritt and Knöll, 2010; Li et al., 2014
	Rho-GEF5	Knöll etal., 2006
	Pak3	Knöll etal., 2006
	EphA4/A7 receptor	Knöll etal., 2006
	Arc	Knöll and Nordheim, 2009; Stritt and Knöll, 2010; Li et al., 2014
	PSD95	Knöll and Nordheim, 2009
	NPAS4	Knöll and Nordheim, 2009
	SRF	Ramanan et al., 2005; Knöll and Nordheim, 2009; Stritt and Knoll, 2010; Li et al., 2014
Egr1/zif268	Fra1	James et al., 2005
	c-jun	James et al., 2005
	SGK	James et al., 2005
	GSK3B	James et al., 2005
	Synapsin, syntaxin, synaptotagmin	Knapska and Kaczmarek, 2004; James et al., 2005; Penke et al., 2014
	Agrin, gephyrin	James etal.,2005
	PSD95	Qin et al., 2015
	GABAA receptor subunits GABRA2, GABRA4, GABRQ	Mo et al., 2015
	Arc	Penke et al., 2011
	cdc20	Conway et al., 2007
	Glutamate dehydrogenase, glutamic acid decarboxylase	Knapska and Kaczmarek, 2004
FosB/ΔFosB	GluA2	Kelz et al., 1999; Vialou et al., 2010
	CaMKIIα	Robison et al., 2013; Robison et al., 2014
	Cdk5	Chen et al., 2000
	SPARC-like 1	Vialou et al., 2010

A list of validated targets of some of the activity-dependent TFs is discussed here, along with references to supporting studies. Neither the gene list nor the references are comprehensive but are rather meant to illustrate (1) the existence of common targets and (2) the fact that many of the known gene targets are directly involved in the molecular mechanisms of synaptic plasticity (see Figure 1C).