Figure 6.
Effect of metyrapone on microglia IL-1β mRNA production. Two hours after saline or metyrapone administration animals were euthanized and microglia isolated for the measurement of IL-1β mRNA in the hippocampus and hypothalamus. A significant interaction was observed between brain region and treatment. * represents significant (P< 0.05) effect of metyrapone compared to vehicle control. Values represent mean IL-1β mRNA fold change compared to vehicle treated animals. Symbols and bars represent group mean ± SEM.