Table S1.
Significantly differentially expressed genes after integrated calculating through RRA method
| Gene symbol | Score | Adjusted P | Gene symbol | Score | Adjusted P |
|---|---|---|---|---|---|
| Upregulated | Downregulated | ||||
| SPINK1 | 5.76E-19 | 3.15E-14 | FCN2 | 1.19E-17 | 6.52E-13 |
| AKR1B10 | 2.75E-17 | 1.50E-12 | CLEC1B | 3.03E-16 | 1.65E-11 |
| HMMR | 1.52E-15 | 8.30E-11 | SLC22A1 | 2.12E-15 | 1.16E-10 |
| ASPM | 5.14E-15 | 2.80E-10 | CXCL14 | 5.14E-15 | 2.80E-10 |
| NDC80 | 1.89E-14 | 1.03E-09 | FCN3 | 8.58E-15 | 4.69E-10 |
| ROBO1 | 2.09E-14 | 1.14E-09 | GLS2 | 1.89E-14 | 1.03E-09 |
| CAP2 | 7.35E-14 | 4.01E-09 | CYP39A1 | 2.31E-14 | 1.26E-09 |
| RACGAP1 | 1.64E-13 | 8.97E-09 | CYP1A2 | 4.86E-14 | 2.65E-09 |
| CCNB1 | 2.14E-13 | 1.17E-08 | CYP2B6 | 5.76E-14 | 3.14E-09 |
| TOP2A | 2.89E-13 | 1.58E-08 | CNDP1 | 7.35E-14 | 4.01E-09 |
| GPC3 | 3.89E-13 | 2.12E-08 | CLEC4M | 1.53E-13 | 8.38E-09 |
| PRC1 | 4.13E-13 | 2.26E-08 | C9 | 2.43E-13 | 1.32E-08 |
| RRM2 | 4.88E-13 | 2.66E-08 | CXCL12 | 4.13E-13 | 2.26E-08 |
| SPP1 | 1.19E-12 | 6.51E-08 | APOF | 7.04E-13 | 3.84E-08 |
| DNAJC6 | 1.42E-12 | 7.78E-08 | ESR1 | 7.78E-13 | 4.25E-08 |
| KIF20A | 1.55E-12 | 8.48E-08 | CRHBP | 1.19E-12 | 6.51E-08 |
| IGF2BP3 | 1.62E-12 | 8.84E-08 | TENM1 | 1.25E-12 | 6.81E-08 |
| PRR11 | 2.17E-12 | 1.18E-07 | GHR | 1.42E-12 | 7.78E-08 |
| MAP2 | 4.74E-12 | 2.59E-07 | DNASE1L3 | 1.62E-12 | 8.86E-08 |
| CDKN2C | 7.05E-12 | 3.85E-07 | ADRA1A | 1.84E-12 | 1.01E-07 |
| DLGAP5 | 8.25E-12 | 4.50E-07 | LPA | 1.92E-12 | 1.05E-07 |
| NUSAP1 | 1.18E-11 | 6.44E-07 | HGF | 2.44E-12 | 1.33E-07 |
| BIRC5 | 2.03E-11 | 1.11E-06 | HAO2 | 3.08E-12 | 1.68E-07 |
| KIF4A | 2.74E-11 | 1.50E-06 | IL1RAP | 3.08E-12 | 1.68E-07 |
| NCAPG | 3.24E-11 | 1.77E-06 | HAMP | 4.62E-12 | 2.52E-07 |
| CCNB2 | 3.81E-11 | 2.08E-06 | IGF1 | 6.20E-12 | 3.39E-07 |
| MAGEA1 | 4.26E-11 | 2.33E-06 | LIFR | 7.05E-12 | 3.85E-07 |
| KIF11 | 5.41E-11 | 2.95E-06 | CYP2C8 | 7.51E-12 | 4.10E-07 |
| AURKA | 6.52E-11 | 3.56E-06 | NAT2 | 8.25E-12 | 4.50E-07 |
| SULT1C2 | 7.39E-11 | 4.03E-06 | FBP1 | 1.08E-11 | 5.90E-07 |
| CCNA2 | 8.28E-11 | 4.52E-06 | LCAT | 1.18E-11 | 6.44E-07 |
| CDK1 | 1.14E-10 | 6.24E-06 | GBA3 | 1.64E-11 | 8.98E-07 |
| E2F8 | 1.76E-10 | 9.63E-06 | NNMT | 1.69E-11 | 9.23E-07 |
| CCNE2 | 2.01E-10 | 1.10E-05 | MARCO | 1.88E-11 | 1.03E-06 |
| BUB1 | 2.04E-10 | 1.12E-05 | SLCO1B3 | 1.89E-11 | 1.03E-06 |
| LCN2 | 2.42E-10 | 1.32E-05 | ALDOB | 2.36E-11 | 1.29E-06 |
| CENPA | 2.80E-10 | 1.53E-05 | RDH16 | 4.26E-11 | 2.33E-06 |
| C1orf112 | 3.06E-10 | 1.67E-05 | SPP2 | 4.65E-11 | 2.54E-06 |
| CDKN3 | 3.45E-10 | 1.88E-05 | CD5L | 6.93E-11 | 3.78E-06 |
| AKR1C3 | 3.87E-10 | 2.11E-05 | MT1M | 7.97E-11 | 4.35E-06 |
| PBK | 6.92E-10 | 3.78E-05 | PLAC8 | 1.16E-10 | 6.34E-06 |
| BUB1B | 7.55E-10 | 4.12E-05 | COLEC11 | 1.18E-10 | 6.45E-06 |
| ECT2 | 9.69E-10 | 5.29E-05 | CYP2C9 | 1.51E-10 | 8.26E-06 |
| EDIL3 | 1.01E-09 | 5.51E-05 | CYP2E1 | 1.65E-10 | 9.00E-06 |
| CDKN2A | 1.05E-09 | 5.71E-05 | SRD5A2 | 1.68E-10 | 9.15E-06 |
| DEPDC1 | 1.11E-09 | 6.05E-05 | GLYAT | 2.11E-10 | 1.15E-05 |
| KIAA0101 | 1.21E-09 | 6.63E-05 | HGFAC | 2.11E-10 | 1.15E-05 |
| TRIM16 | 1.53E-09 | 8.36E-05 | C8orf4 | 2.18E-10 | 1.19E-05 |
| PRKAA2 | 2.31E-09 | 0.000126011 | AFM | 2.32E-10 | 1.27E-05 |
| CDC20 | 2.54E-09 | 0.00013875 | ZG16 | 2.36E-10 | 1.29E-05 |
| EZH2 | 2.69E-09 | 0.00014687 | IGFBP3 | 2.76E-10 | 1.51E-05 |
| TTK | 3.15E-09 | 0.000172213 | ATF5 | 3.02E-10 | 1.65E-05 |
| LEF1 | 3.45E-09 | 0.000188269 | SOCS2 | 3.35E-10 | 1.83E-05 |
| ACSL4 | 4.21E-09 | 0.000230079 | NPY1R | 3.71E-10 | 2.03E-05 |
| CENPF | 5.10E-09 | 0.00027849 | KDM8 | 4.52E-10 | 2.47E-05 |
| DTL | 8.21E-09 | 0.000448485 | COLEC10 | 4.58E-10 | 2.50E-05 |
| MELK | 9.44E-09 | 0.000515558 | MRC1 | 5.11E-10 | 2.79E-05 |
| CDKN2B | 9.76E-09 | 0.000532784 | XDH | 5.61E-10 | 3.06E-05 |
| NEK2 | 1.10E-08 | 0.000603006 | STEAP4 | 6.15E-10 | 3.36E-05 |
| FGF13 | 1.10E-08 | 0.000603006 | MT1F | 6.62E-10 | 3.62E-05 |
| COL15A1 | 1.26E-08 | 0.000686421 | MBL2 | 6.99E-10 | 3.82E-05 |
| CLGN | 1.27E-08 | 0.000692295 | SLC7A2 | 7.17E-10 | 3.92E-05 |
| STXBP6 | 1.85E-08 | 0.00100832 | CYP2C18 | 7.64E-10 | 4.17E-05 |
| ITGA6 | 2.15E-08 | 0.001173191 | DCN | 8.22E-10 | 4.49E-05 |
| RRAGD | 2.20E-08 | 0.001199474 | STAB2 | 8.22E-10 | 4.49E-05 |
| FAM169A | 2.44E-08 | 0.001333329 | CIDEB | 8.43E-10 | 4.60E-05 |
| MAGEA6 | 2.44E-08 | 0.001333329 | CYP4A11 | 9.28E-10 | 5.07E-05 |
| PEG10 | 2.72E-08 | 0.001483161 | CYP2A6 | 9.30E-10 | 5.08E-05 |
| KIF14 | 2.76E-08 | 0.001509308 | RCAN1 | 1.30E-09 | 7.09E-05 |
| SLC7A11 | 2.81E-08 | 0.0015358 | SRPX | 1.32E-09 | 7.22E-05 |
| MAD2L1 | 3.01E-08 | 0.001645264 | ZGPAT | 1.42E-09 | 7.75E-05 |
| ENAH | 3.44E-08 | 0.001878771 | LY6E | 1.45E-09 | 7.92E-05 |
| TKT | 3.62E-08 | 0.001976497 | VNN1 | 1.48E-09 | 8.06E-05 |
| MAGEA3 | 4.38E-08 | 0.002392275 | MASP1 | 1.55E-09 | 8.46E-05 |
| PTTG1 | 4.66E-08 | 0.002544424 | CA2 | 1.69E-09 | 9.21E-05 |
| ZWINT | 5.33E-08 | 0.002913182 | KCNN2 | 1.76E-09 | 9.63E-05 |
| CENPU | 6.08E-08 | 0.003320583 | CXCL2 | 2.01E-09 | 0.000110033 |
| APOBEC3B | 1.17E-07 | 0.006411243 | KBTBD11 | 2.25E-09 | 0.000123013 |
| DLG5 | 1.80E-07 | 0.009808666 | KAZN | 2.34E-09 | 0.000128026 |
| TXNRD1 | 1.94E-07 | 0.010578678 | CETP | 3.07E-09 | 0.000167869 |
| EFCAB2 | 4.75E-07 | 0.025921521 | GYS2 | 3.15E-09 | 0.000172213 |
| CKAP2 | 4.79E-07 | 0.02614349 | MT1G | 3.25E-09 | 0.000177446 |
| SLC38A6 | 5.30E-07 | 0.028919541 | MT1H | 3.35E-09 | 0.000182797 |
| NRCAM | 5.90E-07 | 0.032238372 | GPM6A | 3.60E-09 | 0.000196524 |
| DHRS2 | 6.29E-07 | 0.034360482 | THBS1 | 5.29E-09 | 0.000289149 |
| TPX2 | 6.33E-07 | 0.034574782 | AKR1D1 | 5.81E-09 | 0.000317473 |
| FAT1 | 6.85E-07 | 0.037402125 | MT1E | 6.12E-09 | 0.000334159 |
| SMPX | 8.02E-07 | 0.043778089 | MT1X | 6.28E-09 | 0.000342744 |
| HOXA3 | 8.40E-07 | 0.045901344 | HABP2 | 6.83E-09 | 0.000373189 |
| GREM2 | 7.28E-09 | 0.000397764 | |||
| PLG | 7.64E-09 | 0.000417031 | |||
| GSTZ1 | 7.76E-09 | 0.000423617 | |||
| AGXT | 9.12E-09 | 0.000497916 | |||
| MYO10 | 9.19E-09 | 0.000501698 | |||
| ACSM3 | 9.33E-09 | 0.00050933 | |||
| MOGAT2 | 9.47E-09 | 0.000517054 | |||
| ECM1 | 9.61E-09 | 0.000524872 | |||
| GNMT | 9.88E-09 | 0.000539501 | |||
| ADH1A | 1.05E-08 | 0.000573787 | |||
| ADAMTS13 | 1.18E-08 | 0.000644603 | |||
| ANXA10 | 1.45E-08 | 0.000794344 | |||
| TMEM45A | 1.58E-08 | 0.000861452 | |||
| PDGFRA | 1.67E-08 | 0.000914505 | |||
| TDO2 | 1.74E-08 | 0.000951209 | |||
| ASS1 | 1.77E-08 | 0.000968444 | |||
| FOS | 1.78E-08 | 0.000969969 | |||
| SLC10A1 | 1.85E-08 | 0.00100832 | |||
| BBOX1 | 1.99E-08 | 0.001088418 | |||
| AZGP1 | 2.02E-08 | 0.00110373 | |||
| FGFR2 | 2.15E-08 | 0.001173191 | |||
| EPB41L4B | 2.32E-08 | 0.001269561 | |||
| SH3YL1 | 2.49E-08 | 0.001357476 | |||
| KMO | 2.91E-08 | 0.001589826 | |||
| C7 | 3.17E-08 | 0.00173112 | |||
| ANGPTL6 | 3.23E-08 | 0.001761951 | |||
| ADH1C | 3.58E-08 | 0.001956276 | |||
| PRG4 | 3.62E-08 | 0.001976497 | |||
| CD1D | 3.73E-08 | 0.002036314 | |||
| SLCO4C1 | 3.99E-08 | 0.002176958 | |||
| HBB | 4.05E-08 | 0.002211793 | |||
| FETUB | 4.18E-08 | 0.002282715 | |||
| MT1HL1 | 4.45E-08 | 0.002429655 | |||
| MCC | 4.80E-08 | 0.002623161 | |||
| SHBG | 4.87E-08 | 0.002658396 | |||
| MT2A | 5.49E-08 | 0.003000286 | |||
| IGFALS | 5.68E-08 | 0.00310222 | |||
| RBMS3 | 6.37E-08 | 0.003476853 | |||
| SLC22A7 | 6.37E-08 | 0.003476853 | |||
| PCK1 | 6.71E-08 | 0.00366583 | |||
| CHST4 | 6.84E-08 | 0.003733479 | |||
| HAO1 | 7.67E-08 | 0.004187743 | |||
| OLFML3 | 9.02E-08 | 0.004927537 | |||
| CFP | 1.14E-07 | 0.006235826 | |||
| FAM134B | 1.16E-07 | 0.006333836 | |||
| C6 | 1.20E-07 | 0.00656818 | |||
| GRAMD1C | 1.47E-07 | 0.008021078 | |||
| TFPI2 | 1.64E-07 | 0.008980903 | |||
| TAT | 1.70E-07 | 0.009284924 | |||
| TRPM8 | 1.74E-07 | 0.009491841 | |||
| CPEB3 | 1.76E-07 | 0.009596585 | |||
| BHMT | 1.86E-07 | 0.010133342 | |||
| CYP2A7 | 1.98E-07 | 0.010806761 | |||
| CYP26A1 | 2.06E-07 | 0.011273951 | |||
| NDRG2 | 2.17E-07 | 0.011875047 | |||
| SLC1A1 | 2.36E-07 | 0.012897255 | |||
| KCND3 | 2.41E-07 | 0.01316171 | |||
| ADH6 | 2.58E-07 | 0.014062978 | |||
| HAL | 2.66E-07 | 0.014545375 | |||
| ASPA | 3.05E-07 | 0.016661935 | |||
| ANK3 | 3.05E-07 | 0.016661935 | |||
| F9 | 3.08E-07 | 0.016821456 | |||
| CYP3A4 | 3.17E-07 | 0.017306885 | |||
| ADH1B | 3.58E-07 | 0.019532585 | |||
| CYP2C19 | 3.61E-07 | 0.019712234 | |||
| G6PC | 3.81E-07 | 0.020816234 | |||
| FOSB | 3.99E-07 | 0.021771039 | |||
| OAT | 4.02E-07 | 0.021965865 | |||
| ASPN | 4.39E-07 | 0.023986679 | |||
| ART4 | 4.47E-07 | 0.024406973 | |||
| CYP4F2 | 4.63E-07 | 0.025264069 | |||
| MASP2 | 4.71E-07 | 0.025700965 | |||
| FOLH1B | 5.08E-07 | 0.027737347 | |||
| ACADL | 5.12E-07 | 0.027970839 | |||
| NAMPT | 5.38E-07 | 0.029402819 | |||
| GADD45B | 5.56E-07 | 0.030387478 | |||
| MFAP3L | 5.70E-07 | 0.031142006 | |||
| ITGA9 | 5.94E-07 | 0.032430592 | |||
| SLC19A3 | 6.28E-07 | 0.03430112 | |||
| ABCA8 | 6.80E-07 | 0.037111871 | |||
| FAM13A | 7.23E-07 | 0.039481728 | |||
| PTGIS | 8.10E-07 | 0.044228221 | |||
| EPB41L4A | 8.22E-07 | 0.044891898 | |||
| SERPINA4 | 8.78E-07 | 0.047971072 | |||
| KLKB1 | 8.85E-07 | 0.048322697 | |||
| BCHE | 9.04E-07 | 0.049389145 |