Figure 3.

Tumor Cell Phenotypic Landscape in Breast Cancer

(A) t-SNE plots of normalized marker expression of 180,000 epithelial cells from all samples.

(B) t-SNE highlighting the distribution of cells from tumor, juxta-tumoral, and mammoplasty tissue.

(C) Heatmap of normalized epithelial cell marker expression for 45 epithelial clusters (left) and percentage and total number of cells from mammoplasty (M), juxta-tumoral (JT), and tumor (T) tissue for each cluster (right).

(D and E) Histograms of the expression of epithelial lineage markers in (D) cells derived from juxta-tumoral tissue and (E) cell lines.

(F) Frequencies of cells of individual cluster groups by tumor subtype.

Wilcoxon rank-sum test was used for statistical analysis. ^∗p < 0.05, ^∗∗p < 0.01, ^∗∗∗p < 0.001. See also Figure S3.