Figure S6.

In-Depth Analysis of Relationships in the Tumor Ecosystem, Related to Figure 6

(A) Frequencies of selected T cell clusters for juxta-tumoral and tumor samples. (B) Chord diagrams of the relationships between T cell, myeloid, and epithelial clusters in tumors and matched juxta-tumoral tissue for 41 patients (p ≤ 0.001). (C) Frequencies of selected clusters that differed in correlation between tumor and juxta-tumoral tissue. (D) Absolute number of correlations between clusters for juxta-tumoral (JT) and tumor (T) tissue and table of the fold change between JT and T tissue. (E) Frequency of T cell and TAM phenotypes associated with immunosuppression for TIG1-3. (F) Pseudo-brightfield images of EpCAM and pan cytokeratin on tumor tissue. Rectangles highlight the areas shown at higher magnification in Figure 6E. Scale bar, 50 μm. Spearman correlation and Wilcoxon rank-sum test were used for statistical analysis. ^∗ p < 0.05, ^∗∗ p < 0.01, ^∗∗∗ p < 0.001.